Nick J. Spencer

This study identifies distinct brainstem circuits activated by splanchnic and pelvic spinal afferent pathways from the mouse colorectum, showing their differential roles in sensory processing and visceromotor responses.

The paper identifies Cdh6 as a marker for a novel class of sensory neurons in the mouse colon that regulate colonic motility through specific electrophysiological properties and functional responses.

This paper identifies TRPV4-expressing cell types in the colon and shows limited involvement of TRPV4 in colonic motility.

This study identifies MrgprA3 and MrgprC11 as functional receptors on bladder afferents that induce hypersensitivity to distension when activated, offering a potential therapeutic target for bladder disorders.