The GPR4 antagonist NE-52-QQ57 increases survival, mitigates the hyperinflammatory response and reduces viral load in SARS-CoV-2-infected K18-hACE2 transgenic mice
Xin-Jun Wu, Karen A. Oppelt, Ming Fan, Mona A. Marie, Madison M. Swyers, Ashley J. Williams, Isabelle Lemasson, Rachel L. Roper, Paul Bolin, Li V. Yang
This study shows that the GPR4 antagonist NE-52-QQ57 improves survival, reduces inflammation, and lowers viral load in SARS-CoV-2-infected mice.
Frontiers in Pharmacology · Jul 9, 2025Peer-reviewedPharmacology & Toxicology