LINE-1 activation in the cerebellum drives ataxia
Takehiro Takahashi, Milan Stoiljković, Eric Song, Xiao‐Bing Gao, Yuki Yasumoto, Eriko Kudo, Fernando Carvalho, Yong Kong, Annsea Park, Marya Shanabrough, Klara Szigeti‐Buck, Zhong-Wu Liu, Ashley Kristant, Yalan Zhang, Parker L. Sulkowski, , Akiko Iwasaki
This study shows that activation of young LINE-1 elements in the cerebellum causes ataxia by inducing DNA damage, inflammation, and neuronal dysfunction in mice.
Neuron · Sep 6, 2022Peer-reviewedNeuroscience