Author

Takehiro Takahashi

Yale UniversityORCID 0000-0002-1061-356XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Akiko IwasakiiD· 3 shared Eric SongiD· 2 shared Jon KleiniD· 2 shared Júlio Dos Santos SilvaiD· 2 shared Tianyang MaoiD· 2 shared Abhinav Godavarthi· 1 shared Albert Icksang KoiD· 1 shared Alexander TongiD· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersNeuroscience

Akiko IwasakiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeuroscienceNeuronPeer-reviewedSep 6, 2022

LINE-1 activation in the cerebellum drives ataxia

Takehiro Takahashi, Milan Stoiljković, Eric Song…·Akiko Iwasaki

This study shows that activation of young LINE-1 elements in the cerebellum causes ataxia by inducing DNA damage, inflammation, and neuronal dysfunction in mice.

51 citationstop 4%

mouseDNA methylation

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NeurosciencebioRxivPreprintJan 7, 2022

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Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain

Anthony Fernández-Castañeda, Peiwen Lu, Anna C. Geraghty…·Michelle Monje

Respiratory-restricted SARS-CoV-2 infection in mice, without brain virus, drives white matter microglial reactivity, impaired neurogenesis, oligodendrocyte depletion and myelin loss lasting at least 7 weeks.

100 citations

mousehuman

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BioinformaticsbioRxivPreprintNov 15, 2020

Multiscale PHATE Exploration of SARS-CoV-2 Data Reveals Multimodal Signatures of Disease

Manik Razdan Kuchroo, Jessie Huang, Patrick Wong…·Smita Krishnaswamy

The paper introduces Multiscale PHATE, a method for exploring high-dimensional biomedical data, and applies it to identify immune cell signatures associated with severe COVID-19 outcomes.

7 citations

humanbulk RNA-seq

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