Leonard K. Kaczmarek

The paper shows that Slack channel activation moves FMRP/CYFIP1 from eIF4E to the channel, releasing eIF4E and stimulating translation of β-actin mRNA and cortical β-actin.

The paper investigates how disease-causing gain-of-function mutations in the Slack potassium channel affect excitability differently in excitatory and inhibitory neurons.

The paper shows that HCN channels in L2/3 pyramidal neurons gate NMDA receptor recruitment at thalamic synapses but not cortical synapses, with developmental and neuromodulatory influences.

This study shows that HCN and Slack channels interact in PFC pyramidal neurons to regulate excitability and working memory through a complex that suppresses neuronal firing.

This study shows that activation of young LINE-1 elements in the cerebellum causes ataxia by inducing DNA damage, inflammation, and neuronal dysfunction in mice.