Yong Kong

The paper analyzes bulk RNA-seq data from multiple auditory regions in 5xFAD mice across ages to identify spatiotemporal gene expression changes associated with AD progression.

This study identifies P2x2 receptor upregulation in the cochlea as a cause of hyperacusis, showing that antagonists can reduce hearing hypersensitivity.

This study uses single-cell and spatial sequencing to identify interferon-driven pathways and retroelement expression in cutaneous lupus, showing their association with disease pathology.

This study shows that Cx26 deficiency in the cochlea leads to increased Cx46 expression, which compensates by forming gap junctions in the same locations as Cx26.

This study shows that activation of young LINE-1 elements in the cerebellum causes ataxia by inducing DNA damage, inflammation, and neuronal dysfunction in mice.