Akiko Iwasaki

This paper develops a RIG-I reporter mouse model to track RIG-I expression and function in vivo, revealing its tissue distribution and identifying alveolar macrophages as key sensor cells.

The paper shows that IFNγ and proinflammatory cytokines activate astrocytes to express antigen-presenting machinery, supporting CD4+ T cell restimulation in vitro and in vivo.

The paper identifies persistently activated virus-specific CD8 T cells in long COVID patients, suggesting chronic antigen stimulation by SARS-CoV-2 or herpesvirus.

This study shows that juvenile influenza infection in mice impairs myelin development and leads to lasting cognitive and behavioral issues, which can be mitigated by inhibiting the chemokine receptor CCR3.

This paper develops BEACON, a mucosal adjuvant that enhances protective immunity against HSV-2 in mice by increasing CD8+ TRM populations and mucosal antibody responses.

This study shows nasal anti-CD3 antibody treatment reduces neuroinflammation, enhances neurogenesis, and improves cognitive function in a mouse model of Long COVID.

The paper shows that activating RIG-I in macrophages enhances immunotherapy for glioblastoma by repolarizing tumor-associated macrophages and boosting anti-tumor immune responses.

ImmunoStruct improves immunogenicity prediction by integrating peptide-MHC sequence, structure, and biochemical data, showing better performance than existing methods.

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

Intranasal hemagglutinin boosters after mRNA-LNP vaccination induce mucosal immunity and cross-protection against influenza A virus in mice.

This study uses single-cell and spatial sequencing to identify interferon-driven pathways and retroelement expression in cutaneous lupus, showing their association with disease pathology.

This study identifies bat and mink ACE2 as receptors for HKU5 merbecovirus, revealing distinct receptor interactions and highlighting mustelids as potential intermediate hosts.

This study identifies immune subtypes in hospitalized COVID-19 patients linked to clinical outcomes and long COVID risk through longitudinal multi-omics analysis.

This study shows that activation of young LINE-1 elements in the cerebellum causes ataxia by inducing DNA damage, inflammation, and neuronal dysfunction in mice.

SARS-CoV-2 5' UTR stem-loop 1 (SL1) lets reporters escape Nsp1 translational shutdown. LNA antisense oligos against SL1 restore Nsp1 suppression and reduce infected Vero E6 cells.

Respiratory-restricted SARS-CoV-2 infection in mice, without brain virus, drives white matter microglial reactivity, impaired neurogenesis, oligodendrocyte depletion and myelin loss lasting at least 7 weeks.

The paper introduces FMGAN, a conditional GAN that predicts hard-to-obtain biological information from easy-to-obtain data, demonstrating applications in drug discovery and clinical outcomes.

The paper introduces Multiscale PHATE, a method for exploring high-dimensional biomedical data, and applies it to identify immune cell signatures associated with severe COVID-19 outcomes.

Time-course single-cell RNA sequencing of infected human bronchial epithelial cultures reports ciliated cells as a major target, with tropism later widening to basal and club cells.