Human iPSC-derived neurons identify West Nile virus neuropathogenesis signatures and reveal strain-dependent neuroattenuation
Alejandro Matía, Astrid Anaya, Ali Akgul, Anil Singapuri, Sunny Lee, Jinzhao Wang, Ngan Wagoner, Marius Wernig, Thomas Christian Südhof, Christopher M. Barker, Michael Diamond, Carolina Arias, Ruth Hüttenhain
The paper uses human iPSC-derived neurons to study WNV effects, identifying strain-specific neuroattenuation and pathogenic signatures not seen in conventional cell lines.
bioRxiv · Sep 24, 2026 · PreprintMicrobiology