Nuclear mTOR-Polycomb synergism at developmental gene promoters prone to activation
Persia Akbari Omgba, Gunwant Patil, Maximilian Stötzel, Chieh-Yu Cheng, Henri Niskanen, Max Ruwolt, Aurora Elhazaz Fernandez, Neil P. Blackledge, Astrid Grimme, Fan Liu, Denes Hnisz, Robert J. Klose, Aydan Bulut-Karslıoğlu
The paper identifies mTOR's role in regulating developmental gene promoters in pluripotent mouse embryonic stem cells through interaction with PRC1 and RNA Polymerase II pausing.
bioRxiv · May 2, 2026 · PreprintMolecular Biology