Neil P. Blackledge

Dissection of Polycomb complexes reveals canonical PRC1-independent 3D chromatin interactions

The paper investigates Polycomb-mediated 3D chromatin interactions and finds that cPRC1 is not essential for their formation.

Nuclear mTOR-Polycomb synergism at developmental gene promoters prone to activation

The paper identifies mTOR's role in regulating developmental gene promoters in pluripotent mouse embryonic stem cells through interaction with PRC1 and RNA Polymerase II pausing.

A CpG island-encoded mechanism protects genes from premature transcription termination

The paper identifies a CpG island-encoded mechanism where SET1 complexes interact with WDR82 to prevent premature transcription termination, distinguishing genic from non-genic transcription.

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome

The paper shows that BAP1 limits H2AK119ub1 levels, which affects gene expression and Polycomb complex function, revealing a general mechanism for controlling transcriptional potential.

PRC1 catalytic activity is central to Polycomb system function.

This study investigates the role of PRC1 catalytic activity in Polycomb system function, showing it is essential for chromatin domain formation and gene repression.

Cohesin disrupts polycomb-dependent chromosome interactions

The paper shows cohesin disrupts polycomb-dependent chromosomal interactions to regulate gene repression in embryonic stem cells.

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.

The paper investigates the role of PcG proteins in chromatin accessibility and nucleosome organization in mouse embryonic stem cells, finding that PcG proteins do not significantly affect chromatin accessibility but influence nucleosome occupancy and spacing.