Maximilian Stötzel

The paper identifies mTOR's role in regulating developmental gene promoters in pluripotent mouse embryonic stem cells through interaction with PRC1 and RNA Polymerase II pausing.

The paper shows hypoxia induces an early primitive streak signature in ES cells, enhancing gastruloid elongation and lineage representation through Hif1-mediated transcriptional changes.

The paper identifies lipid metabolism as a key factor in developmental pausing, showing that enhancing fatty acid oxidation extends embryo survival during mTOR inhibition.

This study identifies GATA transcription factors as essential for initiating Xist upregulation and X-chromosome inactivation in mouse embryos through direct activation of a distal enhancer.

This study identifies Chd1's role in repairing DNA breaks in embryonic stem cells, showing its importance in maintaining hypertranscription during development.