MT5-MMP C-terminal mutations reduce C99 and β accumulation: A foundation for peptide-based Alzheimer's interventions
Pedro Belio Mairal, Athina Kamitsou, Delphine Stephan, Nicolas Jullien, Diarra Thiane, Melissa Ramos, Laurence Louis, Florian Benoist, Baptiste Serrano, Marion David, Michel Khrestchatisky, Pascaline Lécorché, Emmanuel Nivet, Santiago Rivera
This study shows that specific mutations in the C-terminal domains of MT5-MMP reduce C99 and Aβ levels, suggesting a potential therapeutic strategy for Alzheimer's disease.
bioRxiv · May 22, 2025 · PreprintCell Biology