Emmanuel Nivet

This study shows that specific mutations in the C-terminal domains of MT5-MMP reduce C99 and Aβ levels, suggesting a potential therapeutic strategy for Alzheimer's disease.

This study compares two hiPSC-derived BBB models, finding that EC-like cells produce high permeability models while EpC-like cells show better barrier properties.

This study identifies MT5-MMP's role in regulating APP processing and Aβ levels through proteolytic and non-proteolytic mechanisms in Alzheimer's disease.

This study shows APOE4 promotes inflammation in human astrocytes by repressing TAGLN3 through HDAC activity, linking it to Alzheimer's disease pathology.