Author

Laurence Louis

Centre National de la Recherche ScientifiqueORCID 0000-0002-4039-5372Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Delphine StephaniD· 2 shared Emmanuel NivetiD· 2 shared Michel KhrestchatiskyiD· 2 shared Nicolas JullieniD· 2 shared Santiago RiveraiD· 2 shared Anne Bernard· 1 shared Athina Kamitsou· 1 shared Baptiste Serrano· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Delphine StephanORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

MT5-MMP C-terminal mutations reduce C99 and β accumulation: A foundation for peptide-based Alzheimer's interventions

Pedro Belio Mairal, Athina Kamitsou, Delphine Stephan, Nicolas Jullien, Diarra Thiane, Melissa Ramos, Laurence Louis, Florian Benoist, Baptiste Serrano, Marion David, Michel Khrestchatisky, Pascaline Lécorché, Emmanuel Nivet, Santiago Rivera

This study shows that specific mutations in the C-terminal domains of MT5-MMP reduce C99 and Aβ levels, suggesting a potential therapeutic strategy for Alzheimer's disease.

bioRxiv · May 22, 2025 · PreprintCell Biology

MT5-MMP controls APP metabolism and the fate of beta-CTF/C99 and Abeta through proteolytic-dependent and -independent mechanisms relevant for Alzheimer's disease

Laura García‐González, Jean‐Michel Paumier, Laurence Louis, Dominika Piłat, Anne Bernard, Delphine Stephan, Nicolas Jullien, Frédéric Checler, Emmanuel Nivet, Michel Khrestchatisky, Kévin Baranger, Santiago Rivera

This study identifies MT5-MMP's role in regulating APP processing and Aβ levels through proteolytic and non-proteolytic mechanisms in Alzheimer's disease.

The FASEB Journal · Jun 12, 2021Peer-reviewedNeuroscience