Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery Patients
Takaya Ishii, Tao Wang, Kazuki Shibata, Shota Nishitani, Takehiko Yamanashi, Nadia E. Wahba, Tomoteru Seki, Kaitlyn J. Thompson, Kyosuke Yamanishi, Tsuyoshi Nishiguchi, Akiyoshi Shimura, Bun Aoyama, Nipun Gorantla, Nathan James Phuong, Hieu Dinh Nguyen, , Gen Shinozaki
This study uses multi-omic analysis of brain tissue from POD patients to show glial cell contributions to pathogenesis, identifying epigenetic and transcriptomic changes in microglia and astrocytes.
bioRxiv · Mar 13, 2025 · PreprintNeuroscience