Takehiko Yamanashi

The paper identifies brain-peripheral DNA methylation sites (BrESS) that consistently predict brain methylation across tissues, showing they are not linked to disease heritability.

This study correlates BSEEG scores with delirium-like behavior in mice, showing age-related differences in the relationship between BSEEG and behavioral outcomes.

This study uses multi-omic analysis of brain tissue from POD patients to show glial cell contributions to pathogenesis, identifying epigenetic and transcriptomic changes in microglia and astrocytes.

This study validates the use of BSEEG in an LPS-induced mouse model of delirium, showing its correlation with behavioral changes and microglial activation.

This study validates the BSEEG method for quantifying post-operative delirium-like states in mice, showing age-related differences in recovery.

This study examines the association between metformin use and DNA methylation profiles in blood samples to explore potential epigenetic mechanisms of aging and longevity.

This study identifies DNA methylation changes associated with post-operative delirium in neurosurgery patients using genome-wide analysis of blood samples.