Sudeshna Das

Subcellular Spatial Profiling Unveils Links Between Neuritic Plaques with Selective Tau Vulnerability in Alzheimer's Disease

The paper uses subcellular spatial transcriptomics to identify why some neurons in Alzheimer's disease accumulate tau while others resist it, finding differences in molecular programs and neuron-glia interactions.

Separation, isolation, and membrane lipid profiling of selectively vulnerable and resilient neurons

This study develops a method to isolate and profile membrane lipids of vulnerable and resilient neurons to investigate their differential responses to oxidative stress.

Krüppel-like factors KLF5 & KLF8 emerge as potential master transcriptional regulators of Alzheimer's disease, as revealed on cell fate regulomes in human brain organoids

The paper identifies KLF5 and KLF8 as master transcriptional regulators in Alzheimer's disease using human brain organoids and gene regulatory network analysis.

Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer's Disease and Primary Tauopathies

The paper uses single-nucleus RNA-seq to analyze cerebrovascular transcriptomic changes in Alzheimer's Disease and primary tauopathies, identifying shared heat-shock responses and disease-specific vascular remodeling.

Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer's disease

This study identifies molecular changes in white matter hyperintensities in Alzheimer's disease using transcriptomic analysis of brain regions and blood vessels.

TYK2 as a novel therapeutic target in Alzheimer Disease

The paper identifies TYK2 as a potential therapeutic target for neurodegenerative diseases by linking cdsRNA-induced inflammation to interferon signaling and demonstrating protective effects of TYK2 inhibitors.

Identification of Novel Biomarkers for Alzheimer's Disease and Related Dementias Using Unbiased Plasma Proteomics

This study identifies novel plasma biomarkers for Alzheimer's disease and related dementias using unbiased proteomics in a large cohort.

Cryopreservation of cerebrospinal fluid cells preserves transcriptomics integrity for single-cell analysis

This study shows that cryopreservation of CSF cells using FBS/DMSO or Recovery media preserves transcriptomic integrity for single-cell analysis, enabling accurate cell type detection and gene expression profiling.

Distinct Transcriptomic Responses to A beta plaques, Neurofibrillary Tangles, and APOE in Alzheimer's Disease

The paper examines transcriptomic changes in Alzheimer's disease brain regions associated with Aβ plaques, tangles, and APOE ε4, finding distinct gene expression patterns linked to neuroinflammation and neuronal dysfunction.

Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms

This study identifies ether lipid biosynthesis as a key pathway mediating the longevity benefits of biguanides like metformin in C. elegans.

Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer's Disease

The paper analyzes endothelial cell heterogeneity across brain regions in Alzheimer's disease using single nucleus RNAseq, revealing region-specific gene expression changes and disease-related transcriptomic alterations.

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease

This study uses single-nucleus RNA-sequencing to analyze astrocyte transcriptomic changes across the spatiotemporal progression of Alzheimer's disease, revealing gene expression trajectories and heterogeneity.

Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid beta aggregates in vivo in a mouse model of Alzheimer's disease

The paper uses real-time imaging to show increased mitochondrial oxidative stress in neurons near Aβ plaques in a mouse model of Alzheimer's disease, and demonstrates that this stress can be reduced by targeting calcium influx or using antioxidants.

Finding associations in a heterogeneous setting: Statistical test for aberration enrichment

The paper introduces a statistical test for detecting heterogeneous effects in omics data and shows its ability to identify disease-relevant genes missed by traditional methods.

Multiplexed fractionated proteomics reveals synaptic factors associated with cognitive resilience in Alzheimer's Disease

The paper uses multiplexed proteomics to identify synaptic factors linked to cognitive resilience in Alzheimer's Disease by analyzing brain tissue from individuals with varying pathology and cognitive outcomes.