Author

Hongdou Li

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alice MoussyiD· 1 shared Anne-Claire Comby· 1 shared Antoine Aubert· 1 shared Aude Bramoulle· 1 shared Benjamin E. GewurziD· 1 shared Bidisha MitraiD· 1 shared Bruno Maria Colombo· 1 shared E.W. Stone· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperSystems Biology

Alice MoussyORCID

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2 papers

Recent·Most cited

Krüppel-like factors KLF5 & KLF8 emerge as potential master transcriptional regulators of Alzheimer's disease, as revealed on cell fate regulomes in human brain organoids

Antoine Aubert, Anne-Claire Comby, Aude Bramoulle, Maria Grazia Mendoza-Ferri, Peggy Azzolin, Hongdou Li, Alice Moussy, Sudeshna Das, Bruno Maria Colombo, Marco Antonio Mendoza-Parra

The paper identifies KLF5 and KLF8 as master transcriptional regulators in Alzheimer's disease using human brain organoids and gene regulatory network analysis.

bioRxiv · Jul 24, 2026 · PreprintSystems Biology

Epstein-Barr virus transformation creates a methionine-dependent ferroptosis vulnerability in B cells

Shaowen White, Rui Guo, Bidisha Mitra, Hongdou Li, Shunji Li, Yifei Liao, Rishi Puri, John M. Asara, E.W. Stone, George Georgiou, Benjamin E. Gewurz

This study shows that methionine restriction induces ferroptosis in EBV-transformed B cells by promoting transsulfuration and glutathione synthesis, and that targeting methionine metabolism can impair tumor growth.

bioRxiv · Jul 13, 2026 · PreprintBiochemistry