No Evidence of Direct Activation of Human Neutrophil Responses by Multivalent Prefusion Trimeric SARS-CoV-2 Spike Protein ex vivo
Audray Fortin, Sandrine Huot, Elise Caron, Cynthia Laflamme, Amélie Pagliuzza, Nicolas Chomont, Caroline Gilbert, Baoshan Zhang, Peter D. Kwong, Marc Pouliot, Nathalie Grandvaux
This study shows that the multivalent prefusion SARS-CoV-2 Spike protein does not directly activate human neutrophils ex vivo, even in the presence of anti-S antibodies.
PLoS ONE · Oct 29, 2025Peer-reviewedImmunology