Baoshan Zhang

Endothelial protein C receptor is an entry receptor for Langya and related parahenipaviruses

The paper identifies endothelial protein C receptor (EPCR) as an entry receptor for Langya and related parahenipaviruses and describes the structural basis of this interaction.

Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

This study uses single-molecule FRET to show that gp41-directed antibodies stabilize or open the prefusion-closed state of HIV-1 Env, revealing two neutralization mechanisms.

A functional investigation of antibody Fc-FcRn variant binding guided by *in silico* free energy perturbation methods

This paper uses free energy perturbation (FEP) calculations to predict and improve the accuracy of Fc-FcRn binding energy changes due to mutations, incorporating conformational changes and coupling effects.

Protective immunity against malaria by a nanoparticle CIS43-based junctional vaccine alone or in combination with R21

This paper develops a nanoparticle-based junctional vaccine targeting PfCSP and compares its efficacy to the R21 vaccine in reducing malaria liver burden in mice.

Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

No Evidence of Direct Activation of Human Neutrophil Responses by Multivalent Prefusion Trimeric SARS-CoV-2 Spike Protein ex vivo

This study shows that the multivalent prefusion SARS-CoV-2 Spike protein does not directly activate human neutrophils ex vivo, even in the presence of anti-S antibodies.

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide

This study compares vaccine-elicited and naturally elicited antibodies' recognition of HIV-1 fusion peptide sequences, finding that naturally elicited antibodies show greater tolerance to sequence variation.

HIV-1-envelope trimer transitions from prefusion-closed to CD4-bound-open conformations through an occluded-intermediate state

This study identifies an occluded-intermediate state in the HIV-1 Env trimer transition pathway using molecular dynamics and smFRET, revealing new structural features and antibody recognition.

Structural survey of HIV-1-neutralizing antibodies targeting Env trimer delineates epitope categories and suggests vaccine templates

The paper analyzes HIV-1 broadly neutralizing antibodies to classify epitopes and identify potential vaccine candidates based on structural and immunological features.