Electrocorticographic and Astrocytic Signatures of Stearoyl-CoA Desaturase Inhibition in the Triple Transgenic Mouse Model of Alzheimer's Disease
Audrey Hector, Tanya Leduc, Maria João da Costa Caiado, Benoît Delignat‐Lavaud, Julien Dufort‐Gervais, Caroline Daneault, Christine Des Rosiers, Clément Bourguignon, Jean‐Marc Lina, Karl J. L. Fernandes, Jonathan Brouillette, Valérie Mongrain
This study investigates whether inhibiting stearoyl-CoA desaturase (SCD) restores sleep in 3xTg-AD mice and affects astrocytic function, finding no significant restoration of sleep patterns but partial rescue of astrocytic changes in the hippocampus.
Neuropharmacology · Jan 13, 2026Peer-reviewedNeuroscience