Karl J. L. Fernandes

Electrocorticographic and Astrocytic Signatures of Stearoyl-CoA Desaturase Inhibition in the Triple Transgenic Mouse Model of Alzheimer's Disease

This study investigates whether inhibiting stearoyl-CoA desaturase (SCD) restores sleep in 3xTg-AD mice and affects astrocytic function, finding no significant restoration of sleep patterns but partial rescue of astrocytic changes in the hippocampus.

In vivo inhibition of stearoyl-CoA desaturase modulates the hippocampal fatty acid profile and restores density of dendritic spines in the aggressive 5xFAD model of Alzheimer s disease

This study shows that inhibiting SCD improves fatty acid profiles and restores dendritic spine density in a 5xFAD Alzheimer's model.

Ketogenic interventions prevent alterations of the gut microbiome in transgenic Alzheimer Disease mice

This study shows ketogenic diets restore gut microbiome alterations in Alzheimer's mice by reducing Bifidobacterium and increasing short-chain fatty acid-producing bacteria.

Ketogenic interventions restore cognition and modulate peripheral metabolic dysfunctions in Alzheimer's disease mouse models

This study shows that two ketogenic diets improve cognition and metabolic health in Alzheimer's disease mouse models, with distinct effects on peripheral metabolism.

More is better: A simple antibody-based strategy for recovering all major mouse brain cell types from multiplexed single-cell RNAseq samples.

The paper introduces a multiplexing strategy for scRNA-seq of adult mouse brain samples using anti-Thy1.2 antibodies and secondary oligonucleotide-labeled antibodies, enabling pooled sequencing with efficient demultiplexing and cost reduction.

Central inhibition of Stearoyl-CoA Desaturase has minimal effects on the peripheral metabolic symptoms of the 3xTg Alzheimer's disease mouse model

This study shows that inhibiting Stearoyl-CoA Desaturase in the brain of 3xTg-AD mice improves cognitive function without affecting peripheral metabolic symptoms.

Impact of in vivo cyclic reprogramming on the choroid plexus

This study investigates the effects of cyclic in vivo OSKM reprogramming on the choroid plexus, finding limited transcriptomic changes but increased NKCC1 expression and minor morphological alterations.