Author

Aurélien Oggier

École Polytechnique Fédérale de Lausanne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1

Frequent Co-Authors

Mahdi HijaziiD· 2 shared P. BarthiD· 2 shared Aditya SengariD· 1 shared Amédé Larabi· 1 shared Byeongseon YangiD· 1 shared Dániel KériiD· 1 shared Florence PojeriD· 1 shared Kelvin LauiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

Mahdi HijaziORCID

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Author profile →

2 papers

Recent·Most cited

Molecular characterization of an adhesion GPCR signal transduction

M. Marfoglia, Louis Dumas, Byeongseon Yang, Aurélien Oggier, Melinda Pedraza, Mahdi Hijazi, Amédé Larabi, Kelvin Lau, Florence Pojer, Michael A. Nash, P. Barth

This study investigates ADGRG1 activation mechanisms through mechanical and allosteric pathways, showing force direction determines signaling via GAIN domain dynamics and introducing engineered variants with tailored sensitivity.

bioRxiv · Aug 14, 2025 · PreprintBiophysics

Computational design of allosteric pathways reprograms ligand-selective GPCR signaling

Mahdi Hijazi, Dániel Kéri, Aurélien Oggier, Aditya Sengar, Melina A. Agosto, Theodore G. Wensel, P. Barth

This study designs GPCR variants with reprogrammed ligand-selective signaling using computational methods, showing sequence variations impact ligand potency and efficacy.

bioRxiv · Aug 13, 2025 · PreprintBiochemistry