Author

Melina A. Agosto

Dalhousie UniversityORCID 0000-0002-3647-1926Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Theodore G. WenseliD· 2 shared Abigail R. MoyeiD· 1 shared Aditya SengariD· 1 shared Alexandre Moulin· 1 shared Andrew P. Rideout· 1 shared Aurélien Oggier· 1 shared Carlo RivoltaiD· 1 shared Dániel KériiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

Theodore G. WenselORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 13, 2025

Computational design of allosteric pathways reprograms ligand-selective GPCR signaling

Mahdi Hijazi, Dániel Kéri, Aurélien Oggier…·P. Barth

This study designs GPCR variants with reprogrammed ligand-selective signaling using computational methods, showing sequence variations impact ligand potency and efficacy.

2 citations

protein structuredeep learning

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Cell BiologybioRxivPreprintJan 20, 2025

Ciliopathy-associated protein, CEP290, is required for ciliary necklace and outer segment membrane formation in retinal photoreceptors.

Abigail R. Moye, Michael A. Robichaux, Melina A. Agosto…·Theodore G. Wensel

This study investigates the role of CEP290 in photoreceptor ciliary structure and outer segment formation in mice, finding defects in ciliary necklace and Y-links, and altered distribution of transition zone proteins.

1 citation

mouseimaging

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Cell BiologyLife Science AlliancePeer-reviewedDec 16, 2024

Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants

Mustansir Pindwarawala, Faiyaz A. K. Abid, Jae Eun Lee…·Melina A. Agosto

The paper investigates mGluR6 mutations in CSNB patients, finding trafficking defects and failure to bind ELFN1 due to impaired Golgi processing.

5 citations

humanproteomics

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