M. Marfoglia

This study investigates ADGRG1 activation mechanisms through mechanical and allosteric pathways, showing force direction determines signaling via GAIN domain dynamics and introducing engineered variants with tailored sensitivity.

AlloPool predicts dynamic allosteric networks in proteins using a graph neural network, outperforming existing models in trajectory reconstruction.

This study investigates the mechanical properties of the ADGRG1 GAIN domain using single-molecule force spectroscopy and simulations, revealing structural mechanisms that enhance mechanical resistance and informing potential drug design.