Structure of the Gq-coupled adhesion receptor ADGRL4, a GPCR implicated in cancer
Qingchao Chen, Anastasiia Gusach, Aurora Diamante, Jayesh C. Patel, Patricia C. Edwards, Christopher G. Tate, David Mordechai Favara
The paper determines the cryo-EM structure of ADGRL4 coupled to Gq, showing weak Gq coupling and distinct interactions compared to other GPCRs, supporting its role in cancer.
bioRxiv · Oct 3, 2025 · PreprintCancer Biology