ASH1L REGULATES THE STRUCTURAL DEVELOPMENT OF NEURONAL CIRCUITRY BY MODULATING BDNF/TrkB SIGNALING IN HUMAN NEURONS
Seon Hye Cheon, Allison M. Culver, Anna M. Bagnell, Foster D. Ritchie, Janay M. Clytus, Mikayla M. McCord, Carin M. Papendorp, Evelyn Chukwurah, Austin J. Smith, Mara H. Cowen, Pankaj S. Ghate, Shannon William Davis, Judy Shih-Hwa Liu, Sofia B. Lizarraga
This study shows ASH1L regulates neuronal connectivity by modulating BDNF/TrkB signaling through its interaction with PRC2 in human neurons, linking ASH1L mutations to autism pathogenesis.
bioRxiv · Feb 18, 2020 · PreprintNeuroscience