A phenotypically robust model of Spinal and Bulbar Muscular Atrophy in Drosophila
Kristin Richardson, Medha Sengupta, Alyson L. Sujkowski, Kozeta Libohova, Autumn C. Harris, Robert J. Wessells, Diane E. Merry, Sokol V. Todi
This paper develops a Drosophila model of SBMA by expressing human AR with pathogenic polyQ repeats, showing motor neuron degeneration and aggregation linked to androgen dependence.
Journal of Neuroscience Research · Dec 8, 2023Peer-reviewedNeuroscience