Robert J. Wessells

The RU486-dependent activation of the GeneSwitch system in adult muscles leads to severe adverse effects in Drosophila

This study shows that activating the GeneSwitch system in adult Drosophila muscles with RU486 causes severe structural and lifespan defects, highlighting the need for careful experimental design.

A phenotypically robust model of Spinal and Bulbar Muscular Atrophy in Drosophila

This paper develops a Drosophila model of SBMA by expressing human AR with pathogenic polyQ repeats, showing motor neuron degeneration and aggregation linked to androgen dependence.

Endurance exercise ameliorates phenotypes in Drosophila models of Spinocerebellar Ataxias

This study shows endurance exercise reduces motor dysfunction and extends lifespan in Drosophila models of SCA2 and SCA6, but not SCA3, through mechanisms involving Sestrin and autophagy.