Kristin Richardson

Androgen Receptor SUMO site mutations ameliorate toxicity in Drosophila models of SBMA

This study shows that mutating SUMOylation sites in the androgen receptor in Drosophila models of SBMA improves longevity but has limited effects on motor performance.

Polyglutamine-expanded TBP rewires neuronal and muscle proteomes beyond transcription in a Drosophila model of SCA17

This study identifies tissue-specific proteomic changes in a Drosophila SCA17 model, showing polyglutamine-expanded TBP affects pathways beyond transcription.

Insights into Dentatorubral-Pallidoluysian Atrophy from a new Drosophila model of disease

This paper develops a Drosophila model of DRPLA by expressing human ATN1 with normal or pathogenic polyglutamine repeats, showing that pathogenic ATN1 causes toxicity and identifies potential therapeutic targets.

Linear ubiquitin chains remodel the proteome and influence the levels of hundreds of regulators in Drosophila

The paper investigates how linear ubiquitin chains affect the proteome in Drosophila by analyzing proteomic changes in flies expressing chains of different lengths.

A phenotypically robust model of Spinal and Bulbar Muscular Atrophy in Drosophila

This paper develops a Drosophila model of SBMA by expressing human AR with pathogenic polyQ repeats, showing motor neuron degeneration and aggregation linked to androgen dependence.

Endurance exercise ameliorates phenotypes in Drosophila models of Spinocerebellar Ataxias

This study shows endurance exercise reduces motor dysfunction and extends lifespan in Drosophila models of SCA2 and SCA6, but not SCA3, through mechanisms involving Sestrin and autophagy.