Association of RhoGEF Ect2 with Desmoplakin Supports RhoA Activity at Intercellular Junctions: Implications for Carvajal Disease
Hoda Zarkoob, Chen Yuan Kam, Jennifer Leigh Koetsier, Avinash Jaiganesh, Erin F. McCarthy, David P. Kelsell, Farah Sheikh, Lisa Marie Godsel, Kathleen Janee Green
The paper identifies Ect2 as a binding partner of desmoplakin, showing its role in maintaining RhoA activity at cell junctions and linking it to Carvajal disease pathology.
bioRxiv · May 21, 2025 · PreprintCell Biology