Jennifer Leigh Koetsier

This study uses scRNA-seq to show Dsg1 coordinates cell proliferation and actin dynamics to drive epidermal morphogenesis through a Dsg1-Nck1-N-WASP axis.

The paper identifies Ect2 as a binding partner of desmoplakin, showing its role in maintaining RhoA activity at cell junctions and linking it to Carvajal disease pathology.

This paper performs RNA-seq on skin samples from three acantholytic diseases to identify shared transcriptomic features and mechanisms of pathogenesis.