Chen Yuan Kam

A regenerative fibroblast competence field supports multiple cell fates in adult skin regeneration

This study identifies NCAM1 as a regulator of regenerative competence in adult skin wounds through single-cell RNA sequencing and functional analysis.

NIR-II squeezed light-field microscopy enables high-speed volumetric imaging of deep-tissue dynamics in vivo

This paper introduces NIR-II squeezed light-field microscopy to enable high-speed volumetric imaging of deep-tissue dynamics in vivo, achieving 600 volumes per second with high resolution.

Skin capillary endothelial cells form a network of spatiotemporally conserved Ca2+ activity

The paper uses intravital imaging to study Ca2+ activity in skin capillaries of live mice, revealing spatiotemporal organization and regulation through gap junctions and L-type Ca2+ channels.

Fibroblast depletion reveals mammalian epithelial resilience across neonatal and adult stages

This study shows that epidermal stem cell proliferative capacity remains unaffected by fibroblast depletion in both adult and neonatal skin, highlighting robust compensatory mechanisms.

Association of RhoGEF Ect2 with Desmoplakin Supports RhoA Activity at Intercellular Junctions: Implications for Carvajal Disease

The paper identifies Ect2 as a binding partner of desmoplakin, showing its role in maintaining RhoA activity at cell junctions and linking it to Carvajal disease pathology.

Mechanisms of vascular maturation and maintenance captured by longitudinal imaging of live mouse skin

This study uses longitudinal imaging to show how vascular maturation and maintenance occur in live mouse skin through vessel regression, EC rearrangement, and VEGFR2 signaling.