Systematic genome-scale identification of host factors for SARS-CoV-2 infection across models yields a core single gene dependency; ACE2
Katherine Chan, Adrian Granda Farias, Hunsang Lee, Furkan Guvenc, Patricia Mero, Kamaldeep Aulakh, Kevin R. Brown, Shahan Haider, Edyta Marcon, Ulrich Braunschweig, Amy H.Y. Tong, Shuye Pu, Andrea Habsid, Natasha Christie-Holmes, Patrick Budylowski, , Jason Moffat
The paper identifies ACE2 as the only common host dependency for SARS-CoV-2 across multiple cell lines, while other host factors are cell line specific.
bioRxiv · Jun 28, 2021 · PreprintSystems Biology