Patricia Mero

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens

The paper develops a method to quantify genetic interactions from CRISPR-Cas9 screens and identifies systematic variations in screen data.

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

Systematic genome-scale identification of host factors for SARS-CoV-2 infection across models yields a core single gene dependency; ACE2

The paper identifies ACE2 as the only common host dependency for SARS-CoV-2 across multiple cell lines, while other host factors are cell line specific.

Systematic mapping of genetic interactions for de novo fatty acid synthesis

This study maps genetic interactions in FASN-deficient cells to identify genes involved in lipid uptake and metabolic adaptation.

Cell cycle regulation of mitochondrial protein import revealed by genome-scale pooled bimolecular fluorescence complementation screening

The paper introduces MaGiCaL-BiFC, a method to identify protein-protein interactions in mammalian cells, and uses it to find novel interactions involving TOMM22, including a mitosis-specific interaction with CK2.

Evaluation and Design of Genome-wide CRISPR/Cas9 Knockout Screens

The paper evaluates CRISPR/Cas9 knockout screens in human cell lines and designs an optimized gRNA library to improve gene knockout efficiency and accuracy.