Megabase-scale detachment of genome-nuclear lamina interactions is required for efficient repair of double stranded breaks
Xabier Vergara, Anna G. Manjón, Marco Novais-Cruz, Marcel de Haas, Ayoub Ouchene, Tom van Schaik, Stefano Giustino Manzo, Richard Cardoso da Silva, Tuncay Baubec, Bas van Steensel, René H. Medema
The paper shows that DSBs in LADs cause megabase-scale detachment from the nuclear lamina, which is necessary for efficient repair.
bioRxiv · Jul 3, 2025 · PreprintCell Biology