Richard Cardoso da Silva

The paper develops a modular cell line platform with synthetic chromatin reader constructs to assess small molecule inhibitors targeting bromodomains in living cells.

The paper shows that DSBs in LADs cause megabase-scale detachment from the nuclear lamina, which is necessary for efficient repair.

This study uses engineered protein probes to track DNA damage dynamics and identify novel DNA damage response factors in living cells and animals.

This study investigates the roles of MBD2 and MBD3 isoforms in NuRD complex function during differentiation, showing that MBD2b can fully rescue MBD3 loss while MBD2t cannot.

The paper introduces ESI mutagenesis, a single-step method for introducing point mutations into BAC transgenes with high precision and efficiency.

The paper maps Pch2 localization during meiotic G2/prophase in budding yeast, showing active transcription and Orc1 are required for its chromatin association, while SC components like Zip1 are also involved.