Tuncay Baubec

This study identifies VRK-1 as a regulator of chromatin-nuclear lamina interactions in C. elegans, showing its role in stress-induced chromatin reorganization and survival.

The paper develops a modular cell line platform with synthetic chromatin reader constructs to assess small molecule inhibitors targeting bromodomains in living cells.

The paper shows that DSBs in LADs cause megabase-scale detachment from the nuclear lamina, which is necessary for efficient repair.

The paper shows that asymmetric bivalent nucleosomes at developmental gene promoters promote a poised state by recruiting repressive H3K27me3 binders and specific chromatin proteins like KAT6B, which is critical for ESC differentiation.

This study uses engineered protein probes to track DNA damage dynamics and identify novel DNA damage response factors in living cells and animals.

The paper identifies SETD2's role in neuronal differentiation by promoting PAF1C interactions with RNA Pol II and shows its requirement for neuronal gene expression during late differentiation stages.

The paper identifies transcription factors and chromatin regulators critical for haemato-endothelial mesoderm formation using CRISPR-Cas9 screens in mouse embryonic stem cells.

This study investigates the roles of MBD2 and MBD3 isoforms in NuRD complex function during differentiation, showing that MBD2b can fully rescue MBD3 loss while MBD2t cannot.

The paper develops a system to study how expanded CAG/CTG repeats affect gene silencing via epigenome editing and finds that repeats reduce silencing effectiveness.

The paper identifies sequence preferences for de novo DNA methylation by DNMT3A and DNMT3B in mouse stem cells, showing structural basis for context-specific methylation.

This study shows TIP5 maintains genome compartmentalization in ground-state pluripotent stem cells by preventing active chromatin from invading repressive domains.

This study investigates whether CAG/CTG repeat expansion alters chromatin folding using 4C sequencing and finds that chromatin contacts remain stable despite repeat expansion.