Physiological folate levels constrain nucleotide synthesis and increase dependence on nucleotide salvage
Ryan Elbashir, Keene L. Abbott, Diya L. Ramesh, Ahmed Ali, Anna Shevzov-Zebrun, Anna M. Barbeau, Michelle Wu, Abigail P. Ward, Yetiş Gültekin, Brian T. Do, Sharanya Sivanand, Azucena Ramos, Tenzin Kunchok, Millenia Waite, Edrees H. Rashan, , Matthew G. Vander Heiden
This study shows that physiological folate levels limit nucleotide synthesis in leukemia cells, making them reliant on salvage pathways for proliferation.
bioRxiv · Sep 14, 2026 · PreprintCancer Biology