Author
Koch Institute for Integrative Cancer Research At MIT
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Mutual co-authors in cluster
7 papers
Recent·Most cited
Ryan Elbashir, Keene L. Abbott, Diya L. Ramesh…·Matthew G. Vander Heiden
This study shows that physiological folate levels limit nucleotide synthesis in leukemia cells, making them reliant on salvage pathways for proliferation.
Mirko Milošević, Kristina Dmytruk, Ahmad Y. Alghadi…·Jakub Rohlena
This paper shows that asparagine enables transsulfuration to restore redox balance in tumors lacking aspartate synthesis enzymes, highlighting transsulfuration as a targetable vulnerability.
Julia Urgel-Solas, Anna Benito, Laura Ortet…·Ana Janic
The paper identifies a metabolic vulnerability in TP53-deficient cells linked to nuclear adenosine metabolism and histone methylation, showing its role in DNA damage response and tumor growth.
Johnathan R. Kent, Keene L. Abbott, Rachel K. Nordgren…·Peggy P. Hsu
This study uses intraoperative arteriovenous sampling to measure tumor metabolism in NSCLC patients, revealing distinct metabolic profiles between tumor and normal lung tissue.
Keene L. Abbott, Sonu Subudhi, Raphaël Ferreira…·Matthew G. Vander Heiden
This study shows that single nutrients do not determine breast cancer metastasis sites, and identifies purine synthesis as a key factor across multiple tissues.
Sarah M Chang, Muhammad Bin Munim, S Trojan…·Matthew G. Vander Heiden
The paper shows cancer cells adjust mitochondrial respiration to alter NAD+/NADH ratios, enhancing biomass synthesis and proliferation under nutrient limitation.
Volha Liaudanskaya, Nicholas J. Fiore, Yang Zhang…·David Lee Kaplan
This study investigates mitochondrial dysregulation's role in neurodegeneration after contusion injury using a 3D in vitro triculture model of human brain cells.