Keene L. Abbott

Physiological folate levels constrain nucleotide synthesis and increase dependence on nucleotide salvage

This study shows that physiological folate levels limit nucleotide synthesis in leukemia cells, making them reliant on salvage pathways for proliferation.

Pancreatic cancer-associated organ dysfunction promotes muscle autophagy and contributes to peripheral tissue wasting

This study shows pancreatic cancer disrupts normal pancreatic function, leading to systemic nutrient depletion and muscle wasting, with autophagy in muscle playing a key role in nutrient redistribution to support tumor growth.

Intraoperative arteriovenous patient sampling to assess in situ non-small cell lung cancer metabolism

This study uses intraoperative arteriovenous sampling to measure tumor metabolism in NSCLC patients, revealing distinct metabolic profiles between tumor and normal lung tissue.

Ribosome-associated quality control of aberrant protein production during amino acid limitation

The paper investigates how amino acid limitation affects translation by analyzing ribosome stalling and the role of RQC pathways and RNF14 in response to arginine depletion.

Site of breast cancer metastasis is independent of single nutrient levels

This study shows that single nutrients do not determine breast cancer metastasis sites, and identifies purine synthesis as a key factor across multiple tissues.

Comparative analysis of plasma and bone marrow nutrient levels in pediatric B-ALL patients

This study compares nutrient levels in plasma and bone marrow of pediatric B-ALL patients, identifying metabolic differences between subtypes and highlighting unique metabolic features in B-ALL circulation.

Sideroflexins enable mitochondrial transport and metabolism of neutral amino acids

The paper identifies sideroflexins as mitochondrial transporters for neutral amino acids and shows functional overlap among paralogues.

Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

The paper shows cancer cells adjust mitochondrial respiration to alter NAD+/NADH ratios, enhancing biomass synthesis and proliferation under nutrient limitation.