Cancer BiologybioRxivPreprint
Physiological folate levels constrain nucleotide synthesis and increase dependence on nucleotide salvage
Ryan Elbashir, Keene L. Abbott, Diya L. Ramesh…·Matthew G. Vander Heiden
This study shows that physiological folate levels limit nucleotide synthesis in leukemia cells, making them reliant on salvage pathways for proliferation.
DOI 10.64898/2026.09.13.750663