HD-PTP/PTPN23 hypomorphic mice display lipodystrophy
B. A. Davies, J. A. Payne, C. P. Martin, D. Schultz, B. G. Childs, C. Zhang, K. Jeganathan, I. Sturmlechner, T. A. White, A. d. Bruin, H. Chen, M. A. Davies, S. Jachim, N. K. LeBrasseur, R. C. Piper, , D. J. Katzmann
This study shows that hypomorphic HD-PTP/PTPN23 mice develop lipodystrophy and reduced adipogenesis, indicating HD-PTP's role in insulin signaling and fat accumulation.
bioRxiv · Aug 2, 2022 · PreprintCell Biology