Author

T. A. White

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

M. A. Silveria· 2 shared M. S. Chapman· 2 shared A. d. Bruin· 1 shared A. Peck· 1 shared A. R. Mashhour· 1 shared A. Tolstikova· 1 shared B. A. Davies· 1 shared B. A. Franca· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

M. A. Silveria

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

HD-PTP/PTPN23 hypomorphic mice display lipodystrophy

B. A. Davies, J. A. Payne, C. P. Martin, D. Schultz, B. G. Childs, C. Zhang, K. Jeganathan, I. Sturmlechner, T. A. White, A. d. Bruin, H. Chen, M. A. Davies, S. Jachim, N. K. LeBrasseur, R. C. Piper, , D. J. Katzmann

This study shows that hypomorphic HD-PTP/PTPN23 mice develop lipodystrophy and reduced adipogenesis, indicating HD-PTP's role in insulin signaling and fat accumulation.

bioRxiv · Aug 2, 2022 · PreprintCell Biology

Cross-species permissivity: structure of a goat adeno-associated virus and its complex with the human receptor, AAVR

E. E. Large, M. A. Silveria, T. A. White, M. S. Chapman

This paper investigates the structure of goat AAVGo.1 and its interaction with human AAVR, revealing two distinct classes of AAV with different receptor-binding modes but conserved atomic interactions.

bioRxiv · Jan 14, 2022Microbiology

Cryo-EM Structure of Adeno-associated virus-4 at 2.2 A resolution

G. M. Zane, M. A. Silveria, N. L. Meyer, T. A. White, M. S. Chapman

The paper presents a high-resolution cryo-EM structure of AAV4 and compares it to other AAVs to explain its inability to bind AAVR domains.

bioRxiv · Jan 12, 2022Microbiology

Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease

S. Günther, P. Y. A. Reinke, D. Oberthuer, O. Yefanov, H. Ginn, S. Meier, T. J. Lane, K. Lorenzen, L. Gelisio, W. Brehm, I. Dunkel, M. Domaracky, S. Saouane, J. Lieske, C. Ehrt, , G

The paper presents the crystal structure of SARS-CoV-2 main protease covalently bound to a metabolite of HEAT, revealing a pro-drug mechanism and potential for non-peptidic inhibitors.

bioRxiv · May 2, 2020 · PreprintBiophysics

Long-term reciprocal gene flow in wild and domestic geese reveals complex domestication history

M. E. Heikkinen, M. Ruokonen, T. A. White, M. M. Alexander, I. Gunduz, K. M. Dobney, J. Aspi, J. B. Searle, T. Pyhäjärvi

This study uses genome-wide markers to infer the timing of European goose domestication and reveals long-term gene flow between wild and domestic geese, including unexpected contributions from Chinese domestic geese.

bioRxiv · Sep 13, 2019Evolutionary Biology