Author

B. A. Himes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:deep learning· 3 Research Focus:benchmarking· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

N. Grigorieff· 3 shared B. A. Lucas· 2 shared A. B. Kleinpeter· 1 shared A. Kotecha· 1 shared C. Aiken· 1 shared D. Sun· 1 shared E. O. Freed· 1 shared J. Liu· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiophysics

N. Grigorieff

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Author profile →

4 papers

Recent·Most cited

Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias

B. A. Lucas, B. A. Himes, N. Grigorieff

This paper improves 2D template matching for cryo-EM by reducing template bias and enabling high-resolution structure determination without relying on the template.

bioRxiv · Jul 3, 2023 · PreprintBiophysics

Locating Macromolecular Assemblies in Cells by 2D Template Matching with cisTEM

B. A. Lucas, B. A. Himes, L. Xue, T. Grant, J. Mahamid, N. Grigorieff

This paper introduces a GPU-accelerated 2D template matching method in cisTEM for identifying macromolecular assemblies in cells, demonstrating its utility for in situ proteomics and structure determination.

bioRxiv · Apr 20, 2021Cell Biology

Cryo-TEM simulations of amorphous radiation-sensitive samples using multislice wave propagation.

B. A. Himes, N. Grigorieff

The paper introduces a new method for simulating cryo-EM images of amorphous samples, improving accuracy by modeling spatially variable inelastic scattering and radiation damage.

bioRxiv · Feb 19, 2021Biophysics

CryoET structures of immature HIV Gag reveal a complete six-helix bundle and stabilizing small molecules distinct from IP6

L. Mendonca, D. Sun, J. Ning, J. Liu, A. Kotecha, M. Olek, T. Frosio, X. Fu, B. A. Himes, A. B. Kleinpeter, E. O. Freed, J. Zhou, C. Aiken, P. Zhang

The paper determines the structure of the HIV Gag six-helix bundle using cryoET and identifies small molecules stabilizing the immature lattice.

bioRxiv · Oct 31, 2020 · PreprintMicrobiology