Author

C. Aiken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:human· 7 Research Focus:cell signaling & trafficking· 3 Assay:structural biology· 2 Assay:ChIP-seq· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Shi· 5 shared J. R. Perilla· 4 shared C. Xu· 3 shared I. Rousso· 3 shared A. Deshpande· 2 shared A. Engelman· 2 shared J. Jennings· 2 shared S. Harel· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersMicrobiology

J. Shi

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Elasticity of the HIV-1 Core Facilitates Nuclear Entry and Infection

A. Deshpande, A. J. Bryer, J. R. Andino-Moncada, J. Shi, J. Hong, C. Torres, S. Harel, A. Francis, J. R. Perilla, C. Aiken, I. Rousso

This study shows that HIV-1 core elasticity is essential for nuclear entry and infection, with capsid-targeting drugs reducing elasticity and impairing infectivity.

PLOS Pathogens · Sep 11, 2024Peer-reviewedBiophysics

The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription

C. Aiken, J. Jennings, H. Bracey, D. T. Nguyen, R. Dasgupta, A. V. Rivera, N. Sluis-Cremer, J. Shi

This study shows that HIV-1 capsid acts as a nanoscale container for reverse transcription, with NERT activity dependent on gp41 and not requiring IP6 or a mature capsid.

bioRxiv · Nov 8, 2023Microbiology

HIV-1 Mutants that Escape the Cytotoxic T-Lymphocytes are Defective in Viral DNA Integration

M. Balasubramaniam, S. Thapa, B.-O. Davids, A. Bryer, C. Xu, J. Shi, C. Aiken, J. Pandhare, J. R. Perilla, C. Dash

This study shows that an HIV-1 mutation escaping CTL response impairs viral DNA integration, and compensatory mutations or host factors can rescue this defect.

bioRxiv · Aug 29, 2021Microbiology

HIV-1 uncoating occurs via a series of rapid biomechanical changes in the core related to individual stages of reverse transcription

S. Rankovic, A. Deshpande, S. Harel, C. Aiken, I. Rousso

This study uses atomic force microscopy to observe stiffness changes in HIV-1 cores during reverse transcription, linking mechanical spikes to specific stages of the process.

bioRxiv · Jan 16, 2021Biophysics

CryoET structures of immature HIV Gag reveal a complete six-helix bundle and stabilizing small molecules distinct from IP6

L. Mendonca, D. Sun, J. Ning, J. Liu, A. Kotecha, M. Olek, T. Frosio, X. Fu, B. A. Himes, A. B. Kleinpeter, E. O. Freed, J. Zhou, C. Aiken, P. Zhang

The paper determines the structure of the HIV Gag six-helix bundle using cryoET and identifies small molecules stabilizing the immature lattice.

bioRxiv · Oct 31, 2020 · PreprintMicrobiology

Chemical Stabilization of the HIV-1 Capsid Results in Efficient HIV-1 Reverse Transcription in vitro

J. Jennings, J. Shi, J. Varadarajan, P. J. Jamieson, C. Aiken

This study shows that stabilizing the HIV-1 capsid with IP6 or HCB enhances reverse transcription efficiency in vitro by maintaining the association of CA and RT proteins with viral cores.

bioRxiv · Sep 17, 2020 · PreprintMicrobiology

A DNA-origami nuclear pore mimic reveals nuclear entry mechanisms of HIV-1 capsid

Q. Shen, C. Xu, S. Jang, Q. Xiong, S. Devarkar, T. Tian, G. Bedwell, T. Tripler, Y. Hu, S. Yuan, J. Temple, J. Shi, C. Aiken, A. Engelman, J. R. Perilla, , Y. Xiong

This study uses DNA-origami NPC mimics to show HIV-1 capsid uses a trimeric interface and RRR motif to pass through nuclear pores, bypassing the FG motif of NUP153.

bioRxiv · Aug 10, 2020 · PreprintMicrobiology

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

C. Xu, D. Fisher, S. Rankovic, W. Li, R. Dick, B. Runge, R. Zadorozhnyi, J. Ahn, C. Aiken, T. Polenova, A. Engelman, Z. Ambrose, I. Rousso, J. R. Perilla

This study investigates how HIV-1 capsid permeability to metabolites affects dNTP import and reverse transcription, revealing a mechanism involving IP6 and BHC.

bioRxiv · Apr 30, 2020Biophysics