Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23
D. Aschenbrenner, M. Quaranta, S. Banerjee, N. Ilott, J. Jansen, B. A. Steere, Y.-H. Chen, S. Ho, K. Cox, Oxford IBD Cohort Investigators, C. V. Arancibia-Carcamo, M. Coles, E. Gaffney, S. Travis, L. A. Denson, , H. H. Uhlig
The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.
bioRxiv · Jan 31, 2020 · PreprintImmunology