Author

D. Aschenbrenner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Approach:deep learning· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. Powrie· 2 shared H. H. Uhlig· 2 shared M. Coles· 2 shared S. Travis· 2 shared A. Filer· 1 shared A. J. Cutler· 1 shared A. Jainarayanan· 1 shared A. Jonsson· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersImmunology

F. Powrie

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3 papers

Recent·Most cited

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

T. Thomas, C. Rich-Griffin, M. Pohin, M. Friedrich, D. Aschenbrenner, J. Pakpoor, A. Jainarayanan, A.-I. Voda, R. Sanches Peres, E. Nee, D. Sathananthan, D. Kotliar, J. Turner, S. Nayar, F. Zhang, , C. Buckley

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

bioRxiv · May 5, 2023Immunology

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23

D. Aschenbrenner, M. Quaranta, S. Banerjee, N. Ilott, J. Jansen, B. A. Steere, Y.-H. Chen, S. Ho, K. Cox, Oxford IBD Cohort Investigators, C. V. Arancibia-Carcamo, M. Coles, E. Gaffney, S. Travis, L. A. Denson, , H. H. Uhlig

The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.

bioRxiv · Jan 31, 2020 · PreprintImmunology

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

D. Trzupek, M. Dunstan, A. J. Cutler, M. Lee, L. Godfrey, D. Aschenbrenner, H. H. Uhlig, L. Wicker, J. A. Todd, R. C. Ferreira

The paper uses a hybrid transcriptomic and proteomic approach to identify CD80 and CD86 as markers of recently activated regulatory T cells in human CD4+ T cells.

bioRxiv · Nov 29, 2019Immunology