S. Ho

Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus

The paper identifies MAT2A as a critical host factor for BKPyV infection through a CRISPR/Cas9 screen and shows a small molecule inhibitor of MAT2A is a potent antiviral drug.

Microwell-Based Flow Culture Increases Viability and Restores Drug Response in Prostate Cancer Spheroids

This study introduces a Microwell Flow Device that improves spheroid viability and drug response in prostate cancer models by reducing hypoxia-related necrosis.

Dispersal of southern elephant seals (Mirounga leonina) from Davis Base, Antarctica: Combining population genetics and tracking data

This study combines genetic and tracking data to analyze the dispersal and genetic diversity of southern elephant seals at Davis Base, Antarctica, identifying their natal origins and foraging behaviors.

Sphingolipid Control of Fibroblast Heterogeneity Revealed by Single-Cell Lipidomics

This study identifies sphingolipid composition as a driver of fibroblast heterogeneity and state transitions using single-cell lipidomics and transcriptomics.

Nef dimerization defect abrogates HIV viremia and associated immune dysregulation in the Bone Marrow-Liver-Thymus-Spleen (BLTS) humanized mouse model

The paper shows that preventing Nef dimerization in HIV reduces viremia and immune dysregulation in a humanized mouse model.

Molecular mode of action of an Acyl Protein thioesterase

The paper investigates the molecular mechanism of APT2, showing it interacts with membranes via a hydrophobic loop and S-acylation, deforms lipid bilayers to extract acyl chains, and is subject to ubiquitination and degradation.

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23

The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.

Utilization of a cell-penetrating peptide-adaptor for delivery of HPV protein E2 into cervical cancer cells to arrest cell growth and promote cell death

This study delivers the HPV E2 protein into cervical cancer cells using a CPP-adaptor system to inhibit proliferation and induce cell death.

Development of humanized mouse and rat models with full-thickness human skin and autologous immune cells

This paper develops humanized mouse and rat models with full-thickness human skin and autologous immune cells to study human host-skin pathogen interactions.

A conserved role of the insulin-like signaling pathway in uric acid pathologies revealed in Drosophila melanogaster

This study shows that the insulin-like signaling pathway influences uric acid metabolism in Drosophila, with conserved effects in humans, and identifies potential therapeutic targets for gout and kidney stones.

A Simulation-Based Evaluation of Total-Evidence Dating Under the Fossilized Birth-Death Process

This paper evaluates total-evidence dating under the fossilized birth-death process through simulations, showing that fossil occurrences significantly impact node time and topology estimates.

The architecture of the endoplasmic reticulum is regulated by the reversible lipid modification of the shaping protein CLIMP-63

This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.

Synchronous diversification of Sulawesi’s iconic artiodactyls driven by recent geological events

The paper tests the hypothesis that recent geological events on Sulawesi drove the synchronous diversification of its endemic artiodactyls, finding that species expanded from a central area that emerged above sea level ~1-2 Myr ago.