M. Coles

Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity

The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

Asparagine availability controls B cell homeostasis

The paper shows asparagine metabolism is critical for B cell function and germinal centre homeostasis, with Asn deprivation impairing survival, proliferation, and immune responses.

Primed to resolve: A single cell atlas of the shoulder capsule reveals a cellular basis for resolving inflammatory fibrosis

This study identifies MERTK+ macrophages and fibroblasts involved in resolving fibrosis in frozen shoulder using single-cell analysis and suggests therapeutic strategies to enhance their interaction.

A glutamine-based single α-helix scaffold to target globular proteins

This paper introduces a method to design peptides that fold into single α-helices using glutamine side chain to main chain hydrogen bonds, enabling targeted interactions with globular proteins.

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23

The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.

Pathologically distinct fibroblast subsets drive inflammation and tissue damage in arthritis

The paper identifies two distinct fibroblast subsets in arthritis that drive inflammation or tissue damage, showing their unique roles in disease progression.

Mapping Local Conformational Landscapes of Proteins in Solution

This paper introduces a method using NMR spectroscopy to map protein conformational landscapes by comparing experimental and expectation spectra, enabling de novo structure determination.